Old Brains
The rats that were tested in this
research are considered senior citizens by the time they are more than 20
months old. Under normal circumstances, beyond that age, their ability to learn
and remember things like how to negotiate mazes begins to slip. But resveratrol
helped their learning abilities stay sharper.
"The results of the study were
striking," says researcher Ashok K. Shetty. "They indicated that for
the control rats who did not receive resveratrol, spatial learning ability was
largely maintained but ability to make new spatial memories significantly
declined between 22 and 25 months. By contrast, both spatial learning and
memory improved in the resveratrol-treated rats."
Ancient Response
Ironically, while stress in your
daily life is considered detrimental to your health, a significant way resveratrol
can improve the health of individual cells is by inducing an ancient stress
response on a cellular level.
"This stress response
represents a layer of biology that has been largely overlooked, and resveratrol
turns out to activate it at much lower concentrations than those used in prior
studies," says researcher Paul Schimmel, who is with the Skaggs Institute
for Chemical Biology at The Scripps Research Institute.
According to Schmimel and his
colleagues, resveratrol latches on to a protein in the cell nucleus called
PARP-1, a substance that takes part in stress responses and increases life
expectancy by helping to repair DNA. By activating PARP-1, resveratrol sets off
a chain reaction of DNA-protection in each cell.ii
And you don't need to consume much
resveratrol to enjoy its benefits. As a matter of fact, the Scripps scientists
think it is better not to get too much.
"Based on these results, it is
conceivable that moderate consumption of a couple glasses of red wine (rich in
resveratrol) would give a person enough resveratrol to evoke a protective
effect via this pathway," says researcher Mathew Sajish.